Epitalon as nootropic

Nootropics are substances that improve cognitive function by producing positive effects on mental performance. They are also called brain boosters or cognitive enhancers.
The term was coined by a Romanian psychologist and chemist Corneliu E. Giurgea from the greek words νους nous, or “mind”, and τρέπειν trepein meaning to turn.

nouvelle-vie-logo-epitalon-click-ENEpitalon itself is not registered as a nootropic, but has similar effects, produced by more natural mechanisms, than classical nootropic substances.
Epitalon is a synthetic peptide based on epithalamin which is produced in the pineal gland  that has the function of regulating the circadian rhythm and melatonin production. Both of this contribute to a better quality sleep that brings better productivity, concentration and cognitive functions to the person.
The evidence is that many people who use epitalon reported that they experienced improved mood, mental clarity and better concentration same as with other nootropics.

Epitalon is an endogenous melatonin secretion stimulant

epitalon-nootropiqueThere are scientific studies and specialized publications about melatonin showing beneficial effects on brain and sleep, but few have investigated the repercussion of introducing large amounts of synthetic melatonin in the body that might have side effects.
The preferred way to take advantage of the benefits of melatonin is to increase the natural production by using stimulants of endogenous melatonin secretion such as epitalon.

“This hormone (melatonin) has been proven to play the key role in biologic rhythm control and exert diverse effects upon the functioning of the endocrine, nervous and immune systems. Reduced melatonin production is considered to entail age-related neurodegenerative changes and certain diseases . Introduction of melatonin produces a geroprotective influence.  However,  this  could  in  some  cases provoke considerable side effects, such as neoplastic growth etc. These circumstances necessitate the search for effective stimulants of endogenous melatonin secretion. Epithalamin and Epitalon –  physiologically active preparations of the pineal gland appear to be among the most promising medications of their kind.” [2]

Both epitalon and melatonin have been shown to contribute to the optimization of the brain cognitive function by  protracted memory and also mnemotropic properties (decreasing the extent of memory disorders). [4]

Nootropics use by students

epitalon-studentNootropics are used more often  by students in academically competitive environments as they are trying to improve performance, concentration and memory.
Recent studies have shown that over 30% of students took a smart drug and the rate is increasing as more people go with this new trend.
Adding epitalon to your stack of nootropics, in this age range, is ideal because besides improving the mental capacities of the brain it also prevents  telomerase shortening ahead of time thus delaying aging.

Calvin Harley talks in TEDMED about the role of telomeres in longevity and mentions that one factor that contributes to telomerases shortening or loss is stress, that is very common in students. So besides the increase in brain health epitalon also stops brain cell aging. [3]

How nootropics or smart drugs work

Main areas that nootropics affect are :

  • Increased neuroplasticity or memory – help with the creation of new synaptic connections and improve the learning process of new information
  • Focus and concentration – by stimulating the release of serotonin and dopamine in the brain that is accompanied by an increase in alertness
  • Better quality of sleep accompanied by an increase in cognitive functions and productivity
  • Improve mood and anti anxiety – an increase in stimulation with greater mental positive energy, concentration and focus and a state of calmness by targeting specific neurotransmitters like GABA (gamma aninobutryic acid)  

Nootropics and side effects

The main concern with the use  of cognitive enhancers is the side effects many drugs have.
One of the requirements that a substance to be placed in categories nootropic, as it was defined by their creator, Dr Cornelius Giurgea is to be safe and non toxic for the brain.
As seen in numerous studies the use of the synthetic pineal peptide Epitalon (Ala-Glu-Asp-Gly) has not side effects or toxicity.

“Long-term exposure to Epitalon in small doses did not show any toxic effect.” [5]

Nootropics have neuroprotective properties that can slow the signs of aging on the brain and prevent the cognitive decline seen in the elderly. Also they help in maintaining the basic structures found in brain cells and have antioxidant effects.

The best nootropic regimen or stack

This is a common question in the nootropics. Many users begin with a single substance either be it a more natural kind like coffee, ginkgo biloba or synthesis most notably Piracetam.
For starters it’s okay, but for consistent results it is ideal to combine multiple substances for more powerful synergistic effects.
Also many search for the best nootropics substance or drug there is but every substance has better result in some fields like memory, concentration or better cognitive process so it is a good idea to try what works best for you.
Epitalon has good nootropics effects as related by users and it has been shown to have no side effects or toxicity, and it can enhance the power of other nootropics and also prevent aging of body cells as well as brain cells.

References :

  1. Nootropic Wikipedia. https://en.wikipedia.org/wiki/Nootropic
  2. Synthetic tetrapeptide epitalon restores disturbed neuroendocrine regulation in senescent monkeys http://www.nel.edu/22_4/NEL220401A03_Khavinson_w.pdf
  3. What do telomeres tell you about longevity? http://www.tedmed.com/talks/show?id=7252
  4. Comparative study of the effects of melatonin and epitalon on the protracted memory under the shuttle labyrinth test conditions in rats in the course of aging https://www.ncbi.nlm.nih.gov/pubmed/17209456
  5. Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice. https://www.ncbi.nlm.nih.gov/pubmed/16634527